154619-51-9
Chemical Structure
MF 268
- CAS No.: 154619-51-9
- Formula:C28H46N4O3
- Molecular Weight:486.70
IUPAC Name: (3aS,8aR)-1,3a,8-trimethyl-1,2,3,3a,8,8a-hexahydropyrrolo[2,3-b]indol-5-yl (8-((2S,6R)-2,6-dimethylmorpholino)octyl)carbamate
InChIKey: CJMJXTWMGXRFOM-FKTURHEWSA-N
SMILES: C[C@]12C=3C(N(C)[C@]1(N(C)CC2)[H])=CC=C(OC(NCCCCCCCCN4C[C@H](C)O[C@H](C)C4)=O)C3
Biological Activity: MF 268 is an orally active, blood-brain barrier-permeable acetylcholinesterase (AChE) inhibitor with an IC50 of 9 nM in rats. MF 268 binds to both the catalytic site and the regulatory anionic site of acetylcholinesterase, and increases the extracellular levels of acetylcholine, norepinephrine, dopamine and serotonin in the rat cortex via a dose-dependent pathway. MF 268 exhibits anti-amnesic effects in rats. MF 268 can be used in research related to Alzheimer's disease[1][2].
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MF 268 | MF 268 is an orally active, blood-brain barrier-permeable acetylcholinesterase (AChE) inhibitor with an IC50 of 9 nM in rats. MF 268 binds to both the catalytic site and the regulatory anionic site of acetylcholinesterase, and increases the extracellular levels of acetylcholine, norepinephrine, dopamine and serotonin in the rat cortex via a dose-dependent pathway. MF 268 exhibits anti-amnesic effects in rats. MF 268 can be used in research related to Alzheimer's disease. | |||||||||||||||||||||
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References
- [1]. Zhu XD, et al. Effects of MF-268, a new cholinesterase inhibitor, on acetylcholine and biogenic amines in rat cortex. Journal of neuroscience research. 1996 Jan 01;43(1):120-6.
- [2]. Braida D, et al. Long-lasting antiamnesic effect of a novel anticholinesterase inhibitor (MF268). Pharmacology, biochemistry, and behavior. 1998 Apr;59(4):897-901.
