154675-18-0
154675-18-0
Chemical Structure
HBDDE
- CAS No.: 154675-18-0
- Formula:C16H18O8
- Molecular Weight:338.31
IUPAC Name: 6,6'-bis(methoxymethyl)-[1,1'-biphenyl]-2,2',3,3',4,4'-hexaol
InChIKey: NEBCAMAQXZIVRE-UHFFFAOYSA-N
SMILES: OC1=CC(COC)=C(C2=C(C(O)=C(C=C2COC)O)O)C(O)=C1O
Biological Activity: HBDDE, a derivative of Ellagic acid, is an isoform-selective PKCα and PKCγ inhibitor with IC50s of 43 μM and 50 μM, respectively. HBDDE shows selective for PKCα/PKCγ over PKCδ, PKCβI and PKCβII isozymes. HBDDE induces neuronal apoptosis[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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HBDDE | 98.03% | HBDDE, a derivative of Ellagic acid, is an isoform-selective PKCα and PKCγ inhibitor with IC50s of 43 μM and 50 μM, respectively. HBDDE shows selective for PKCα/PKCγ over PKCδ, PKCβI and PKCβII isozymes. HBDDE induces neuronal apoptosis. | ||||||||||||||||||||
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References
- [1]. A Mathur, et al. 2,2',3,3',4,4'-Hexahydroxy-1,1'-biphenyl-6,6'-dimethanol dimethyl ether (HBDDE)-induced neuronal apoptosis independent of classical protein kinase C alpha or gamma inhibition. Biochem Pharmacol. 2000 Sep 15;60(6):809-15. [Content Brief]
- [2]. Y Kashiwada, et al. New hexahydroxybiphenyl derivatives as inhibitors of protein kinase C. J Med Chem. 1994 Jan 7;37(1):195-200. [Content Brief]
