154801-74-8
Chemical Structure
(R)-Efavirenz
Synonym(s): (R)-DMP 266; (R)-EFV; (R)-L-743726
- CAS No.: 154801-74-8
- Formula:C14H9ClF3NO2
- Molecular Weight:315.67
IUPAC Name: (R)-6-chloro-4-(cyclopropylethynyl)-4-(trifluoromethyl)-1,4-dihydro-2H-benzo[d][1,3]oxazin-2-one
InChIKey: XPOQHMRABVBWPR-CYBMUJFWSA-N
SMILES: FC(F)(F)[C@]1(C2=CC(Cl)=CC=C2NC(O1)=O)C#CC3CC3
Biological Activity: (R)-Efavirenz ((R)-DMP 266) is a non-nucleoside reverse transcriptase inhibitor that acts by non-competitive inhibition of the viral enzyme. (R)-Efavirenz can be metabolized by CYP2B6 to 8-hydroxyefavirenz in a highly stereoselective manner. (R)-Efavirenz is promising to be a useful probe for the CYP2B6 active site and catalytic mechanisms[1][2].
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(R)-Efavirenz | (R)-Efavirenz ((R)-DMP 266) is a non-nucleoside reverse transcriptase inhibitor that acts by non-competitive inhibition of the viral enzyme. (R)-Efavirenz can be metabolized by CYP2B6 to 8-hydroxyefavirenz in a highly stereoselective manner. (R)-Efavirenz is promising to be a useful probe for the CYP2B6 active site and catalytic mechanisms. | |||||||||||||||||||||
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References
- [1]. Maggiolo F. Efavirenz. Expert Opin Pharmacother. 2007 Jun;8(8):1137-45. [Content Brief]
- [2]. Wang PF, et al. Efavirenz Metabolism: Influence of Polymorphic CYP2B6 Variants and Stereochemistry. Drug Metab Dispos. 2019 Oct;47(10):1195-1205. doi: 10.1124/dmd.119.086348. Epub 2019 Jul 19. Erratum in: Drug Metab Dispos. 2019 Oct;47(10):1231. [Content Brief]
