1548116-54-6
Chemical Structure
SN34037
- CAS No.: 1548116-54-6
- Formula:C15H19Cl2N3O2
- Molecular Weight:344.24
IUPAC Name: (4-(2,4-dichlorophenyl)piperazin-1-yl)(morpholino)methanone
InChIKey: ZVSJDUNUGMVNIL-UHFFFAOYSA-N
SMILES: O=C(N1CCN(CC1)C2=CC=C(C=C2Cl)Cl)N3CCOCC3
Biological Activity: SN34037 is a specific inhibitor of Aldo-keto reductase 1C3 (AKR1C3, EC 1.1.1.188) with the ability to inhibit the cytotoxic activity of PR-104A. SN34037-sensitive coumberone reduction provides a rapid and specific assay for AKR1C3 activity. SN34037 inhibits the aerobic cytotoxicity of PR-104A in TF1 erythroleukemia cells with high AKR1C3 expression, but not in Nalm6 pre-B acute lymphoblastic leukemia cells with low AKR1C3 expression[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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SN34037 | 99.02% | SN34037 is a specific inhibitor of Aldo-keto reductase 1C3 (AKR1C3, EC 1.1.1.188) with the ability to inhibit the cytotoxic activity of PR-104A. SN34037-sensitive coumberone reduction provides a rapid and specific assay for AKR1C3 activity. SN34037 inhibits the aerobic cytotoxicity of PR-104A in TF1 erythroleukemia cells with high AKR1C3 expression, but not in Nalm6 pre-B acute lymphoblastic leukemia cells with low AKR1C3 expression. | ||||||||||||||||||||
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