155428-00-5
155428-00-5
Chemical Structure
Alniditan dihydrochloride
Synonym(s): Alnitidan dihydrochloride
- CAS No.: 155428-00-5
- Formula:C17H28Cl2N4O
- Molecular Weight:375.34
IUPAC Name: (R)-N1-(chroman-2-ylmethyl)-N3-(1,4,5,6-tetrahydropyrimidin-2-yl)propane-1,3-diamine dihydrochloride
InChIKey: GDNITZYKOOTAFK-QCUBGVIVSA-N
SMILES: [H]Cl.[H]Cl.C1(NCCCNC[C@H]2CCC3=CC=CC=C3O2)=NCCCN1
Biological Activity: Alniditan (Alnitidan) dihydrochloride is a potent 5-HT1B and 5-HT1D receptors agonist, with IC50s of 1.7 nM and 1.3 nM for h5-HT1B and h5-HT1D receptors in HEK293 cells, respectively. Alniditan dihydrochloride has migraine-preventive effects[1][2].
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Alniditan dihydrochloride | 99.70% | Alniditan (Alnitidan) dihydrochloride is a potent 5-HT1B and 5-HT1D receptors agonist, with IC50s of 1.7 nM and 1.3 nM for h5-HT1B and h5-HT1D receptors in HEK293 cells, respectively. Alniditan dihydrochloride has migraine-preventive effects. | ||||||||||||||||||||
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References
- [1]. Limmroth V, et al. Effects of alniditan on neurogenic oedema in the rat dura mater and on contraction of rat basilar artery. Eur J Pharmacol. 1999 Oct 8;382(2):103-9. [Content Brief]
- [2]. Lesage AS, et al. Agonistic properties of alniditan, sumatriptan and dihydroergotamine on human 5-HT1B and 5-HT1D receptors expressed in various mammalian cell lines. Br J Pharmacol. 1998 Apr;123(8):1655-65. [Content Brief]
