155521-45-2
Chemical Structure
Alisol F
- CAS No.: 155521-45-2
- Formula:C30H48O5
- Molecular Weight:488.70
IUPAC Name: (2aR,6aS,6bS,7S,9R,11S,12aS,13aR,13bS)-11-((R)-1,2-dihydroxy-2-methylpropyl)-7-hydroxy-3,3,6a,9,13a,13b-hexamethyl-1,2a,3,5,6,6a,6b,7,8,9,10,11,12a,13,13a,13b-hexadecahydronaphtho[2',1':4,5]indeno[2,1-b]pyran-4(2H)-one
InChIKey: YNKJSQIXVXWFBK-SLGDLKFASA-N
SMILES: C[C@]1(C(C[C@@H]2O)=C([C@@H]3C)[C@](O[C@@]([C@@H](O)C(C)(O)C)([H])C3)([H])C1)[C@]([C@]2([H])[C@]4(CCC5=O)C)(CC[C@@]4([H])C5(C)C)C
Biological Activity: Alisol F is a protostane-type triterpenoid with anti-inflammatory and anti-hepatitis B virus activities. Alisol F inhibits LPS (HY-D1056)-induced phosphorylation of ERK, JNK, p38, STAT3 and NF-κB (p65), suppresses the production of NO, IL-6, TNF-α and IL-1β, and also downregulates the levels of iNOS and COX-2. Alisol F reduces the serum alanine aminotransferase and aspartate aminotransferase levels in mice with acute liver injury and ameliorates their liver pathological damage[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Alisol F | 99.89% | Alisol F is a protostane-type triterpenoid with anti-inflammatory and anti-hepatitis B virus activities. Alisol F inhibits LPS (HY-D1056)-induced phosphorylation of ERK, JNK, p38, STAT3 and NF-κB (p65), suppresses the production of NO, IL-6, TNF-α and IL-1β, and also downregulates the levels of iNOS and COX-2. Alisol F reduces the serum alanine aminotransferase and aspartate aminotransferase levels in mice with acute liver injury and ameliorates their liver pathological damage. | ||||||||||||||||||||
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References
- [1]. Bi X, et al. Anti-Inflammatory Activities and Liver Protection of Alisol F and 25-Anhydroalisol F through the Inhibition of MAPK, STAT3, and NF-κB Activation In Vitro and In Vivo. Molecules. 2017;22(6):951. Published 2017 Jun 8. [Content Brief]
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[2]. Jiang ZY, et al. A new triterpene and anti-hepatitis B virus active compounds from Alisma orientalis. Planta medica. 2006 Aug;72(10):951-4.
