155547-93-6
Chemical Structure
Discobahamin A
- CAS No.: 155547-93-6
- Formula:C47H65N9O11
- Molecular Weight:932.07
IUPAC Name: 2-hydroxy-N-(1-(((12Z,20Z)-17-((5-hydroxy-1H-indol-3-yl)methyl)-6-isobutyl-2-methyl-4,5,8,10,16,19-hexaoxo-3,7,15,18-tetraaza-1(2,4)-oxazola-9(2,1)-pyrrolidinacyclohenicosaphan-20-en-11-yl)amino)-1-oxopentan-2-yl)-3-methylpentanamide
InChIKey: QHBNCVKMHIROBF-KKEVCDKESA-N
SMILES: O=C1/C=C\C2=COC([C@@H](C)NC(C([C@@H](CC(C)C)NC([C@@H]3N(CCC3)C([C@H](CCCNC([C@@H](CC4=CNC5=C4C=C(O)C=C5)N1)=O)NC([C@H](CCC)NC(C(C(CC)C)O)=O)=O)=O)=O)=O)=O)=N2
Biological Activity: Discobahamin A is a cyclic peptide with a side chain, a 24-membered macrocyclic cyclic peptide containing an α-ketoamide functional group, and Antifungal agent. Discobahamin A exists in a new species of the deep-sea sponge genus Discodermia from the Bahamas. Discobahamin A inhibits the growth of yeast-form Candida albicans. Discobahamin A is applicable to research related to Candida albicans infections[1][2].
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Discobahamin A | Discobahamin A is a cyclic peptide with a side chain, a 24-membered macrocyclic cyclic peptide containing an α-ketoamide functional group, and Antifungal agent. Discobahamin A exists in a new species of the deep-sea sponge genus Discodermia from the Bahamas. Discobahamin A inhibits the growth of yeast-form Candida albicans. Discobahamin A is applicable to research related to Candida albicans infections. | |||||||||||||||||||||
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References
- [1]. Gunasekera SP, et al. Discobahamins A and B, new peptides from the Bahamian deep water marine sponge Discodermia sp. Journal of natural products. 1994 Jan;57(1):79-83.
- [2]. Yang B, et al. Total Synthesis of Discobahamin A and Putative Structure of Discobahamin B via an Isocyanide-based Macrocyclization Reaction. Angewandte Chemie (International ed. in English). 2025 Mar 03;64(10):e202419383.
