1558598-41-6
1558598-41-6
Chemical Structure
PFM01
- CAS No.: 1558598-41-6
- Formula:C14H15NO2S2
- Molecular Weight:293.40
IUPAC Name: (Z)-5-(4-hydroxybenzylidene)-3-isobutyl-2-thioxothiazolidin-4-one
InChIKey: GPURHDUTZUYAFI-GHXNOFRVSA-N
SMILES: O=C1N(CC(C)C)C(S/C1=C\C2=CC=C(O)C=C2)=S
Biological Activity: PFM01, N-alkylated Mirin derivative, is a MRE11 endonuclease inhibitor. PFM01 can regulate double-strand break repair (DSBR) by nonhomologous end-joining (NHEJ) versus homologous recombination (HR)[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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PFM01 | 99.91% | PFM01, N-alkylated Mirin derivative, is a MRE11 endonuclease inhibitor. PFM01 can regulate double-strand break repair (DSBR) by nonhomologous end-joining (NHEJ) versus homologous recombination (HR). | ||||||||||||||||||||
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References
- [1]. Shibata A, et, al. DNA double-strand break repair pathway choice is directed by distinct MRE11 nuclease activities. Mol Cell. 2014 Jan 9; 53(1): 7-18. [Content Brief]
- [2]. Völkening L, et, al. RAD50 regulates mitotic progression independent of DNA repair functions. FASEB J. 2020 Feb; 34(2): 2812-2820. [Content Brief]
