155969-82-7
Chemical Structure
Rabdoternin E
- CAS No.: 155969-82-7
- Formula:C21H30O7
- Molecular Weight:394.46
InChIKey: UHERRNNNKBWWKU-JUTGNHQTSA-N
SMILES: O[C@]12[C@]34[C@](CC[C@](C(C4=O)=C)([H])C3O)([H])[C@@]5([C@@H](O2)OC)C(C(C)(CC[C@H]5O)C)([H])[C@@H]1O
Biological Activity: Rabdoternin E is a potential anti-inflammatory and antitumor agent. 2α-Acetoxy-14,15-cyclopimara-7β,16-diol only inhibits nitric oxide (NO) production in lipopolysaccharide (LPS)-induced RAW264.7 macrophages (IC50=2.3 μM) and exhibits cytotoxicity against human tumor cells such as HL-60 and SW-480 (IC50 values ??of 2.6 μM and 4.1 μM, respectively). Rabdoternin E is an ent-kaurane-type diterpenoid compound that can be naturally extracted from the 70% acetone aqueous extract of the aerial parts of Isodon rosthornii (Diels) Hara (a plant of the Lamiaceae family, Isodon genus)[1].
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Rabdoternin E | Rabdoternin E is a potential anti-inflammatory and antitumor agent. 2α-Acetoxy-14,15-cyclopimara-7β,16-diol only inhibits nitric oxide (NO) production in lipopolysaccharide (LPS)-induced RAW264.7 macrophages (IC50=2.3 μM) and exhibits cytotoxicity against human tumor cells such as HL-60 and SW-480 (IC50 values ??of 2.6 μM and 4.1 μM, respectively). Rabdoternin E is an ent-kaurane-type diterpenoid compound that can be naturally extracted from the 70% acetone aqueous extract of the aerial parts of Isodon rosthornii (Diels) Hara (a plant of the Lamiaceae family, Isodon genus). | |||||||||||||||||||||
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