156579-02-1
Chemical Structure
MX-68
- CAS No.: 156579-02-1
- Formula:C22H24N8O5S
- Molecular Weight:512.54
IUPAC Name: (S)-2-(4-((2,4-diaminopteridin-6-yl)methyl)-3,4-dihydro-2H-benzo[b][1,4]thiazine-7-carboxamido)hexanedioic acid
InChIKey: WEEYASWRWODDTJ-ZDUSSCGKSA-N
SMILES: O=C(O)[C@@H](NC(C1=CC=C2N(CC3=NC4=C(N)N=C(N)N=C4N=C3)CCSC2=C1)=O)CCCC(O)=O
Biological Activity: MX-68 is an orally active antifolate agent. MX-68 can prolong the lifespan of MRL/lpr mice, delay the onset of proteinuria, and inhibit the elevation of serum blood urea nitrogen and cholesterol levels. MX-68 is also an anti-rheumatic agent, which exerts potent antiproliferative effects on rheumatoid arthritis-related cells and can inhibit arthritis in rats. MX-68 can be used in the research of autoimmune diseases such as autoimmune kidney disease and rheumatoid arthritis[1][2].
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MX-68 | MX-68 is an orally active antifolate agent. MX-68 can prolong the lifespan of MRL/lpr mice, delay the onset of proteinuria, and inhibit the elevation of serum blood urea nitrogen and cholesterol levels. MX-68 is also an anti-rheumatic agent, which exerts potent antiproliferative effects on rheumatoid arthritis-related cells and can inhibit arthritis in rats. MX-68 can be used in the research of autoimmune diseases such as autoimmune kidney disease and rheumatoid arthritis. | |||||||||||||||||||||
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References
- [1]. Maruyama N, et al. An improved process for the large-scale preparation of antirheumatic agent MX-68. Organic process research & development, 2004, 8(6): 883-888.
- [2]. Mihara M, et al. A novel antifolate, MX-68, inhibits the development of autoimmune disease in MRL/lpr mice. Int Arch Allergy Immunol. 1997 Aug;113(4):454-9. [Content Brief]
