157000-76-5
157000-76-5
Chemical Structure
Datelliptium chloride hydrochloride
- CAS No.: 157000-76-5
- Formula:C23H29Cl2N3O
- Molecular Weight:434.40
IUPAC Name: 2-(2-(diethylamino)ethyl)-9-hydroxy-5,11-dimethyl-6H-pyrido[4,3-b]carbazol-2-ium chloride hydrochloride
InChIKey: QLZIAISICLKYOX-UHFFFAOYSA-N
SMILES: [H]Cl.CC1=C2C(NC3=C2C=C(O)C=C3)=C(C)C4=CC=[N+](CCN(CC)CC)C=C41.[Cl-]
Biological Activity: Datelliptium chloride hydrochloride is a DNA-intercalating agent derived from Ellipticine (HY-15753). Datelliptium chloride hydrochloride is effective in vivo against a variety of murine solid tumors[1][2].
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Datelliptium chloride hydrochloride | Datelliptium chloride hydrochloride is a DNA-intercalating agent derived from Ellipticine (HY-15753). Datelliptium chloride hydrochloride is effective in vivo against a variety of murine solid tumors. | |||||||||||||||||||||
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References
- [1]. Donato MT, et al. Toxicity of the antitumoral drug datelliptium in hepatic cells: Use of models in vitro for the prediction of toxicity in vivo. Toxicol In Vitro. 1992 Jul;6(4):295-302. [Content Brief]
- [2]. Mucci-LoRusso P, et al. Activity of datelliptium acetate (NSC 311152; SR 95156A) against solid tumors of mice. Invest New Drugs. 1990 Aug;8(3):253-61. [Content Brief]
