157013-85-9
157013-85-9
Chemical Structure
U-89843A hydrochloride
Synonym(s): PNU-89843 hydrochloride
- CAS No.: 157013-85-9
- Formula:C16H24ClN5
- Molecular Weight:321.85
IUPAC Name: 6,7-dimethyl-2,4-di(pyrrolidin-1-yl)-7H-pyrrolo[2,3-d]pyrimidine hydrochloride
InChIKey: MNKBXPNQWKUSKU-UHFFFAOYSA-N
SMILES: CN1C(C)=CC2=C(N3CCCC3)N=C(N4CCCC4)N=C21.[H]Cl
Biological Activity: U-89843A (PNU-89843) hydrochloride is a GABAA receptors positive allosteric modulator (PAM). U-89843A hydrochloride enhances GABA-induced Cl- currents in the α1β2γ2, α3β2γ2 and α6β2γ2 subtypes. U-89843A hydrochloride shows antioxidant and sedative effects[1][2].
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U-89843A hydrochloride | U-89843A (PNU-89843) hydrochloride is a GABAA receptors positive allosteric modulator (PAM). U-89843A hydrochloride enhances GABA-induced Cl- currents in the α1β2γ2, α3β2γ2 and α6β2γ2 subtypes. U-89843A hydrochloride shows antioxidant and sedative effects. | |||||||||||||||||||||
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References
- [1]. Im HK, Im WB, et al. U-89843A is a novel allosteric modulator of gamma-aminobutyric acidA receptors. J Pharmacol Exp Ther. 1995 Dec;275(3):1390-5. [Content Brief]
- [2]. Bundy GL, et al. Synthesis of novel 2,4-diaminopyrrolo-[2,3-d]pyrimidines with antioxidant, neuroprotective, and antiasthma activity. J Med Chem. 1995 Oct 13;38(21):4161-3. [Content Brief]
