157066-77-8
157066-77-8
Chemical Structure
SNAP5089 hydrochloride
- CAS No.: 157066-77-8
- Formula:C36H41ClN4O5
- Molecular Weight:645.19
IUPAC Name: methyl 5-((3-(4,4-diphenylpiperidin-1-yl)propyl)carbamoyl)-2,6-dimethyl-4-(4-nitrophenyl)-1,4-dihydropyridine-3-carboxylate hydrochloride
InChIKey: MXELDPKESKXREN-UHFFFAOYSA-N
SMILES: O=C(C1=C(C)NC(C)=C(C(NCCCN2CCC(C3=CC=CC=C3)(C4=CC=CC=C4)CC2)=O)C1C5=CC=C([N+]([O-])=O)C=C5)OC.[H]Cl
Biological Activity: SNAP5089 (hydrochloride) is a selective α1A adrenergic receptor antagonist. SNAP5089 (hydrochloride) can be used in the research of hypertension and benign prostatic hyperplasia[1][2].
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SNAP5089 hydrochloride | SNAP5089 (hydrochloride) is a selective α1A adrenergic receptor antagonist. SNAP5089 (hydrochloride) can be used in the research of hypertension and benign prostatic hyperplasia. | |||||||||||||||||||||
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References
- [1]. Proudman RGW, et al. The affinity and selectivity of α-adrenoceptor antagonists, antidepressants, and antipsychotics for the human α1A, α1B, and α1D-adrenoceptors. Pharmacol Res Perspect. 2020 Aug;8(4):e00602. [Content Brief]
- [2]. Wetzel JM, et al. Discovery of alpha 1a-adrenergic receptor antagonists based on the L-type Ca2+ channel antagonist niguldipine. J Med Chem. 1995 May 12;38(10):1579-81. [Content Brief]
