157798-13-5
157798-13-5
Chemical Structure
5-(Nonyloxy)tryptamine oxalate
- CAS No.: 157798-13-5
- Formula:C21H32N2O5
- Molecular Weight:392.49
IUPAC Name: 2-(5-(nonyloxy)-1H-indol-3-yl)ethanamine oxalate
InChIKey: JORSCLBFSAAOFR-UHFFFAOYSA-N
SMILES: NCCC1=CNC2=C1C=C(OCCCCCCCCC)C=C2.O=C(O)C(O)=O
Biological Activity: 5-(Nonyloxy)tryptamine oxalate, a high-affinity agonist for the 5-HTIDβ receptor, with an ED50 value of 68 nM. 5-(Nonyloxy)tryptamine oxalate, exhibits antitumor growth activity in vivo and enhances the ability of T cells to target tumor cells[1][2].
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5-(Nonyloxy)tryptamine oxalate | 5-(Nonyloxy)tryptamine oxalate, a high-affinity agonist for the 5-HTIDβ receptor, with an ED50 value of 68 nM. 5-(Nonyloxy)tryptamine oxalate, exhibits antitumor growth activity in vivo and enhances the ability of T cells to target tumor cells. | |||||||||||||||||||||
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References
- [1]. Glennon R A, et al. 5-(Nonyloxy) tryptamine: a novel high-affinity 5-HT1D. Beta. Serotonin receptor agonist[J]. Journal of medicinal chemistry, 1994, 37(18): 2828-2830. [Content Brief]
- [2]. Stachura P, et al. Unleashing T cell anti-tumor immunity: new potential for 5-Nonloxytryptamine as an agent mediating MHC-I upregulation in tumors. Mol Cancer. 2023 Aug 15;22(1):136. doi: 10.1186/s12943-023-01833-8. PMID: 37582744; PMCID: PMC10426104. [Content Brief]
