1580484-33-8
1580484-33-8
Chemical Structure
Mcl-1 inhibitor 10
- CAS No.: 1580484-33-8
- Formula:C21H15F3O4
- Molecular Weight:388.34
IUPAC Name: 4-hydroxy-2'-((3-(trifluoromethyl)phenoxy)methyl)-[1,1'-biphenyl]-3-carboxylic acid
InChIKey: GBUJCCFRKREBDP-UHFFFAOYSA-N
SMILES: O=C(C1=CC(C2=C(COC3=CC=CC(C(F)(F)F)=C3)C=CC=C2)=CC=C1O)O
Biological Activity: Mcl-1 inhibitor 10 (compound 43) is a relatively strong MCL-1 inhibitor (IC50=0.67 μM). Mcl-1 inhibitor 10 interacts with specific binding sites of MCL-1 protein to block the pro-survival signal of MCL-1 and push cancer cells into apoptosis. Mcl-1 inhibitor 10 can be used in the study of MCL-1 dependent cancers[1].
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Mcl-1 inhibitor 10 | Mcl-1 inhibitor 10 (compound 43) is a relatively strong MCL-1 inhibitor (IC50=0.67 μM). Mcl-1 inhibitor 10 interacts with specific binding sites of MCL-1 protein to block the pro-survival signal of MCL-1 and push cancer cells into apoptosis. Mcl-1 inhibitor 10 can be used in the study of MCL-1 dependent cancers. | |||||||||||||||||||||
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