1580501-97-8
Chemical Structure
(2E)-TCO-PNB ester
- CAS No.: 1580501-97-8
- Formula:C15H17NO5
- Molecular Weight:291.30
IUPAC Name: (E)-cyclooct-2-en-1-yl (4-nitrophenyl) carbonate
InChIKey: XNTGBHHUEQUWSQ-GQCTYLIASA-N
SMILES: O=C(OC1=CC=C([N+]([O-])=O)C=C1)OC2/C=C/CCCCC2
Biological Activity: (2E)-TCO-PNB ester is an active reaction substrate with the properties of trans-cyclooctene derivatives. The core chemical property of (2E)-TCO-PNB ester is its ability to undergo efficient inverse electron-demand Diels-Alder (IEDDA) cycloaddition with tetrazine groups. (2E)-TCO-PNB ester can be used in ligation reactions to verify the integrity of tetrazine groups, and also serves as a key synthetic raw material for the preparation of the prodrug TCO-DOX. (2E)-TCO-PNB ester is applied in research related to drug synthesis and bioorthogonal chemistry[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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(2E)-TCO-PNB ester | 99.46% | (2E)-TCO-PNB ester is an active reaction substrate with the properties of trans-cyclooctene derivatives. The core chemical property of (2E)-TCO-PNB ester is its ability to undergo efficient inverse electron-demand Diels-Alder (IEDDA) cycloaddition with tetrazine groups. (2E)-TCO-PNB ester can be used in ligation reactions to verify the integrity of tetrazine groups, and also serves as a key synthetic raw material for the preparation of the prodrug TCO-DOX. (2E)-TCO-PNB ester is applied in research related to drug synthesis and bioorthogonal chemistry. | ||||||||||||||||||||
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References
- [1]. Zhang Q, et al. Bio-inspired biorthogonal compartmental microparticles for tumor chemotherapy and photothermal therapy. J Nanobiotechnology. 2024;22(1):498. Published 2024 Aug 20. [Content Brief]
- [2]. García-Vázquez R, et al. [11 C]Carboxylated Tetrazines for Facile Labeling of Trans-Cyclooctene-Functionalized PeptoBrushes. Macromol Rapid Commun. 2022;43(12):e2100655. [Content Brief]
