158054-02-5
Chemical Structure
BE-31405
- CAS No.: 158054-02-5
- Formula:C28H36O10
- Molecular Weight:532.58
IUPAC Name: (1R,3aR,4S,4aR,7R,7aR,8aS)-8a-((((2R,3aS,5R,6R,6aS)-6-acetoxy-7-hydroxytetrahydro-2,5-methanofuro[2,3-d][1,3]dioxol-2-yl)oxy)methyl)-4-formyl-3-isopropyl-7-methyl-4,4a,5,6,7,7a,8,8a-octahydro-1,4-methano-s-indacene-3a(1H)-carboxylic acid
InChIKey: ULHRLJDDVCQHQE-GHJBWDERSA-N
SMILES: O=C([C@]12C(C(C)C)=C[C@]3([H])[C@@]1(CO[C@]4(C5O)O[C@]6([H])[C@](O[C@@]5([H])[C@H]6OC(C)=O)([H])O4)C[C@]7([H])[C@H](C)CC[C@@]7([H])[C@@]2(C=O)C3)O
Biological Activity: BE-31405 is an antifungal antibiotic. BE-31405 can be isolated from the culture broth of the fungal strains such as Penicillium minioluteum F31405, Talaromyces siamensis FKA-61, and Phomopsis sp. FKA-62. BE-31405 exhibits potent growth inhibitory activity against pathogenic fungal strains including Candida albicans, Candida glabrata, and Cryptococcus neoformans. BE-31405 shows no cytotoxicity against mammalian cells[1][2].
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BE-31405 | BE-31405 is an antifungal antibiotic. BE-31405 can be isolated from the culture broth of the fungal strains such as Penicillium minioluteum F31405, Talaromyces siamensis FKA-61, and Phomopsis sp. FKA-62. BE-31405 exhibits potent growth inhibitory activity against pathogenic fungal strains including Candida albicans, Candida glabrata, and Cryptococcus neoformans. BE-31405 shows no cytotoxicity against mammalian cells. | |||||||||||||||||||||
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References
- [1]. Okada, H., et al., (1998). BE-31405, a new antifungal antibiotic produced by Penicillium minioluteum. I. Description of producing organism, fermentation, isolation, physico-chemical and biological properties. The Journal of antibiotics, 51(12), 1081-1086. [Content Brief]
- [2]. Nonaka, K.,et al., (2015). Induced production of BE-31405 by co-culturing of Talaromyces siamensis FKA-61 with a variety of fungal strains. The Journal of antibiotics, 68(9), 573-578. [Content Brief]
