158440-71-2
158440-71-2
Chemical Structure
(-)-Irofulven
Synonym(s): MGI 114; 6-Hydroxymethylacylfulvene; NSC 683863
- CAS No.: 158440-71-2
- Formula:C15H18O3
- Molecular Weight:246.31
IUPAC Name: (R)-6'-hydroxy-3'-(hydroxymethyl)-2',4',6'-trimethylspiro[cyclopropane-1,5'-inden]-7'(6'H)-one
InChIKey: NICJCIQSJJKZAH-AWEZNQCLSA-N
SMILES: CC(C1(CC1)[C@@](O)(C2=O)C)=C3C2=CC(C)=C3CO
Biological Activity: (-)-Irofulven (MGI 114), an Illudin S analog, is a DNA alkylating agent. (-)-Irofulven inhibits the replication of DNA, induces tumor cells apoptosis, and has potent antitumor activity[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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(-)-Irofulven | 95.55% | (-)-Irofulven (MGI 114), an Illudin S analog, is a DNA alkylating agent. (-)-Irofulven inhibits the replication of DNA, induces tumor cells apoptosis, and has potent antitumor activity. | ||||||||||||||||||||
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References
- [1]. Yutian Wang, et al. Irofulven induces replication-dependent CHK2 activation related to p53 status. Biochem Pharmacol. 2007 Feb 15;73(4):469-80. [Content Brief]
- [2]. H S Friedman, et al. Activity of irofulven (6-hydroxymethylacylfulvene) in the treatment of glioblastoma multiforme-derived xenografts in athymic mice. Cancer Chemother Pharmacol. 2001 Nov;48(5):413-6. [Content Brief]
