15854-08-7
Chemical Structure
aPKC-IN-2
- CAS No.: 15854-08-7
- Formula:C14H15NO2S
- Molecular Weight:261.34
IUPAC Name: ethyl 2-amino-4-(p-tolyl)thiophene-3-carboxylate
InChIKey: GOQSMGNEJVWZIG-UHFFFAOYSA-N
SMILES: O=C(C1=C(SC=C1C2=CC=C(C=C2)C)N)OCC
Biological Activity: aPKC-IN-2 is a small molecule inhibitor that inhibits aPKC activity. aPKC-IN-2 can effectively block vascular endothelial permeability in cell culture and in vivo experiments. aPKC-IN-2 shows biological activity in interfering with NFκB-driven gene transcription and is associated with inflammatory responses. aPKC-IN-2 has a significant inhibitory effect on vascular endothelial permeability induced by VEGF and TNF, and its EC50 value is in the low nanomolar range. The structural characteristics of aPKC-IN-2 reveal key elements of its inhibitory activity, providing the possibility for further development of small molecule aPKC inhibitors[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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aPKC-IN-2 | 99.80% | aPKC-IN-2 is a small molecule inhibitor that inhibits aPKC activity. aPKC-IN-2 can effectively block vascular endothelial permeability in cell culture and in vivo experiments. aPKC-IN-2 shows biological activity in interfering with NFκB-driven gene transcription and is associated with inflammatory responses. aPKC-IN-2 has a significant inhibitory effect on vascular endothelial permeability induced by VEGF and TNF, and its EC50 value is in the low nanomolar range. The structural characteristics of aPKC-IN-2 reveal key elements of its inhibitory activity, providing the possibility for further development of small molecule aPKC inhibitors. | ||||||||||||||||||||
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