15861-24-2
15861-24-2
Chemical Structure
5-Cyanoindole
- CAS No.: 15861-24-2
- Formula:C9H6N2
- Molecular Weight:142.16
IUPAC Name: 1H-indole-5-carbonitrile
InChIKey: YHYLDEVWYOFIJK-UHFFFAOYSA-N
SMILES: N#CC1=CC=C2NC=CC2=C1
Biological Activity: 5-Cyanoindole is a human myeloperoxidase (MPO) inhibitor. 5-Cyanoindole specifically inhibits breast cancer cell proliferation. 5-Cyanoindole can be used in research on inflammation and breast cancer[1][2][3][4][5][6].
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5-Cyanoindole | 99.95% | 5-Cyanoindole is a human myeloperoxidase (MPO) inhibitor. 5-Cyanoindole specifically inhibits breast cancer cell proliferation. 5-Cyanoindole can be used in research on inflammation and breast cancer. | ||||||||||||||||||||
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References
- [1]. Jantschko W, et al. Exploitation of the unusual thermodynamic properties of human myeloperoxidase in inhibitor design. Biochemical pharmacology. 2005 Apr 15;69(8):1149-57.
- [2]. Heinrich T, et al. Synthesis and structure--activity relationship in a class of indolebutylpiperazines as dual 5-HT(1A) receptor agonists and serotonin reuptake inhibitors. Journal of medicinal chemistry. 2004 Sep 09;47(19):4684-92. [Content Brief]
- [3]. Muñoz-Ruiz P, et al. Design, synthesis, and biological evaluation of dual binding site acetylcholinesterase inhibitors: new disease-modifying agents for Alzheimer's disease. Journal of medicinal chemistry. 2005 Nov 17;48(23):7223-33.
- [4]. Tarleton M, et al. Cytotoxic 2-phenyacrylnitriles, the importance of the cyanide moiety and discovery of potent broad spectrum cytotoxic agents. European journal of medicinal chemistry. 2012 Nov;57:65-73.
- [5]. Hatzenbuhler NT, et al. Advances toward new antidepressants with dual serotonin transporter and 5-HT1A receptor affinity within a class of 3-aminochroman derivatives. Part 2. Journal of medicinal chemistry. 2008 Nov 13;51(21):6980-7004. [Content Brief]
- [6]. Koli P, et al. Structure‐Activity Relationship of Indolylkojylmethane Based on Antiproliferative Activity against Breast Cancer. ChemistrySelect. 2020 Oct 29;5(40):12417-20.
