159565-60-3
Chemical Structure
L 738372
- CAS No.: 159565-60-3
- Formula:C18H15N3O
- Molecular Weight:289.33
IUPAC Name: (S)-4-cyclopropyl-4-(pyridin-2-ylethynyl)-3,4-dihydroquinazolin-2(1H)-one
InChIKey: GRKPBOOXGCBIQK-GOSISDBHSA-N
SMILES: O=C1NC2=C([C@@](C#CC3=NC=CC=C3)(C4CC4)N1)C=CC=C2
Biological Activity: L-738372 is a non-competitive reversible inhibitor of HIV-1 reverse transcriptase (RT) with an inhibition constant (Ki) of 140 nM against dTTP. When combined with any nucleoside analogs (such as azidothymidine triphosphate, didexoyinosine triphosphate, or didexoycytidine triphosphate), L-738372 exhibits synergistic inhibition of RT activity. L-738372 has 2-3 times more inhibitory potency against the azidothymidine-resistant RT (D67N, K70R, T215Y, K219Q) compared to the wild-type RT. L-738372 holds promise for research in the field of HIV virus treatment[1].
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L 738372 | L-738372 is a non-competitive reversible inhibitor of HIV-1 reverse transcriptase (RT) with an inhibition constant (Ki) of 140 nM against dTTP. When combined with any nucleoside analogs (such as azidothymidine triphosphate, didexoyinosine triphosphate, or didexoycytidine triphosphate), L-738372 exhibits synergistic inhibition of RT activity. L-738372 has 2-3 times more inhibitory potency against the azidothymidine-resistant RT (D67N, K70R, T215Y, K219Q) compared to the wild-type RT. L-738372 holds promise for research in the field of HIV virus treatment. | |||||||||||||||||||||
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References
- [1]. Carroll S S, et al. Inhibition of HIV-1 reverse transcriptase by a quinazolinone and comparison with inhibition by pyridinones. Differences in the rates of inhibitor binding and in synergistic inhibition with nucleoside analogs[J]. Journal of Biological Chemistry, 1994, 269(51): 32351-32357. [Content Brief]
