1596-56-1
Chemical Structure
Naphthol AS-MX phosphate
Synonym(s): NASTRp
- CAS No.: 1596-56-1
- Formula:C19H18NO5P
- Molecular Weight:371.32
IUPAC Name: 3-((2,4-dimethylphenyl)carbamoyl)naphthalen-2-yl dihydrogen phosphate
InChIKey: IOMLBTHPCVDRHM-UHFFFAOYSA-N
SMILES: O=C(C1=C(OP(O)(O)=O)C=C2C=CC=CC2=C1)NC3=CC=C(C)C=C3C
Biological Activity: Naphthol AS-MX phosphate (NASTRp) is a small molecule inhibitor of the CREB (cyclic adenosine phosphate reaction element binding protein)-CBP (CREB binding protein) transcription factor complex. Naphthol AS-MX phosphate shows antitumor activity against lung cancer cells, inhibiting tumor cell proliferation (IC50=3.701 μmol/L), colony formation, and anchored independent growth in soft AGAR. Naphthol AS-MX phosphate can be used in the study of KRAS mutated lung cancer, especially for KRAS mutated lung cancer with poor chemotherapy resistance and prognosis[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Naphthol AS-MX phosphate | 99.50% | Naphthol AS-MX phosphate (NASTRp) is a small molecule inhibitor of the CREB (cyclic adenosine phosphate reaction element binding protein)-CBP (CREB binding protein) transcription factor complex. Naphthol AS-MX phosphate shows antitumor activity against lung cancer cells, inhibiting tumor cell proliferation (IC50=3.701 μmol/L), colony formation, and anchored independent growth in soft AGAR. Naphthol AS-MX phosphate can be used in the study of KRAS mutated lung cancer, especially for KRAS mutated lung cancer with poor chemotherapy resistance and prognosis. | ||||||||||||||||||||
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