1596348-32-1
1596348-32-1
Chemical Structure
KDM5-C70
- CAS No.: 1596348-32-1
- Formula:C17H28N4O3
- Molecular Weight:336.43
IUPAC Name: ethyl 2-(((2-((2-(dimethylamino)ethyl)(ethyl)amino)-2-oxoethyl)amino)methyl)isonicotinate
InChIKey: WCILOMUUNVPIKQ-UHFFFAOYSA-N
SMILES: O=C(C1=CC(CNCC(N(CCN(C)C)CC)=O)=NC=C1)OCC
Biological Activity: KDM5-C70 is an ethyl ester derivative of KDM5-C49 and a potent, cell-permeable and pan-KDM5 histone demethylase inhibitor. KDM5-C70 has an antiproliferative effect in myeloma cells, leading to genome-wide elevation of H3K4me3 levels[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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KDM5-C70 | 98.82% | KDM5-C70 is an ethyl ester derivative of KDM5-C49 and a potent, cell-permeable and pan-KDM5 histone demethylase inhibitor. KDM5-C70 has an antiproliferative effect in myeloma cells, leading to genome-wide elevation of H3K4me3 levels. | ||||||||||||||||||||
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References
- [1]. Johansson C, et al. Structural analysis of human KDM5B guides histone demethylase inhibitor development. Nat Chem Biol. 2016 Jul;12(7):539-45. [Content Brief]
- [2]. Blair LP, et al. KDM5 lysine demethylases are involved in maintenance of 3'UTR length. Sci Adv. 2016 Nov 18;2(11):e1501662. [Content Brief]
