1597426-52-2
1597426-52-2
Chemical Structure
T-448 free base
- CAS No.: 1597426-52-2
- Formula:C17H20N4OS
- Molecular Weight:328.43
IUPAC Name: 3-((1S,2R)-2-(cyclobutylamino)cyclopropyl)-N-(5-methyl-1,3,4-thiadiazol-2-yl)benzamide
InChIKey: HQRYNOVKRKLADI-LSDHHAIUSA-N
SMILES: O=C(NC1=NN=C(C)S1)C2=CC=CC([C@H]3[C@H](NC4CCC4)C3)=C2
Biological Activity: T-448 free base is a specific, orally active, CNS-penetrant and irreversible inhibitor of lysine-specific demethylase 1 (LSD1, an H3K4 demethylase), with an IC50 of 22 nM. T-448 free base enhances H3K4 methylation in primary cultured rat neurons[1].
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T-448 free base | T-448 free base is a specific, orally active, CNS-penetrant and irreversible inhibitor of lysine-specific demethylase 1 (LSD1, an H3K4 demethylase), with an IC50 of 22 nM. T-448 free base enhances H3K4 methylation in primary cultured rat neurons. | |||||||||||||||||||||
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