159857-65-5
Chemical Structure
MC-Phe-Lys(MMT)-PABOH
- CAS No.: 159857-65-5
- Formula:C52H57N5O7
- Molecular Weight:864.04
IUPAC Name: (S)-2-((S)-2-(6-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)hexanamido)-3-phenylpropanamido)-N-(4-(hydroxymethyl)phenyl)-6-(((4-methoxyphenyl)diphenylmethyl)amino)hexanamide
InChIKey: JZJLLDINRJFDCM-ZYBCLOSLSA-N
SMILES: O=C(C=CC1=O)N1CCCCCC(N[C@@H](CC2=CC=CC=C2)C(N[C@H](C(NC3=CC=C(C=C3)CO)=O)CCCCNC(C4=CC=CC=C4)(C5=CC=CC=C5)C6=CC=C(C=C6)OC)=O)=O
Biological Activity: MC-Phe-Lys(MMT)-PABOH is a linker. MC-Phe-Lys(MMT)-PABOH can be used to synthesize the immunoconjugate BR96-Phe-Lys-PABC-DOX. MC-Phe-Lys(MMT)-PABOH can be used in the research of colorectal cancer and ovarian cancer[1][2].
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MC-Phe-Lys(MMT)-PABOH | MC-Phe-Lys(MMT)-PABOH is a linker. MC-Phe-Lys(MMT)-PABOH can be used to synthesize the immunoconjugate BR96-Phe-Lys-PABC-DOX. MC-Phe-Lys(MMT)-PABOH can be used in the research of colorectal cancer and ovarian cancer. | |||||||||||||||||||||
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References
- [1]. Dubowchik GM, et al. Cathepsin B-labile dipeptide linkers for lysosomal release of doxorubicin from internalizing immunoconjugates: model studies of enzymatic drug release and antigen-specific in vitro anticancer activity. Bioconjug Chem. 2002 Jul-Aug;13(4):855-69. [Content Brief]
- [2]. Yao H, et al. Methods to Design and Synthesize Antibody-Drug Conjugates (ADCs). Int J Mol Sci. 2016 Feb 2;17(2):194. [Content Brief]
