1604034-78-7
Chemical Structure
IRAK4-IN-29
- CAS No.: 1604034-78-7
- Formula:C22H21N3O4
- Molecular Weight:391.42
IUPAC Name: 2-methoxy-3-(2-(2-methoxyethoxy)ethoxy)-11H-indolo[3,2-c]quinoline-9-carbonitrile
InChIKey: UWLYVPPIZPRYQY-UHFFFAOYSA-N
SMILES: N#CC1=CC=C2C(NC3=C2C=NC4=CC(OCCOCCOC)=C(C=C43)OC)=C1
Biological Activity: IRAK4-IN-29 is an IRAK4 inhibitor with good selectivity and low nanomolar activity. IRAK4-IN-29 can effectively block the TLR-mediated signal transduction pathway. IRAK4-IN-29 showed significant inhibitory effects in LPS- and R848-induced cytokine experiments. IRAK4-IN-29 can inhibit LPS-induced TNFα in an in vivo model, showing a similar phenotype to IRAK4 gene-deficient mice. IRAK4-IN-29 has good medicinal chemical properties, such as microsomal stability and solubility, showing potential clinical application value[1].
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IRAK4-IN-29 | IRAK4-IN-29 is an IRAK4 inhibitor with good selectivity and low nanomolar activity. IRAK4-IN-29 can effectively block the TLR-mediated signal transduction pathway. IRAK4-IN-29 showed significant inhibitory effects in LPS- and R848-induced cytokine experiments. IRAK4-IN-29 can inhibit LPS-induced TNFα in an in vivo model, showing a similar phenotype to IRAK4 gene-deficient mice. IRAK4-IN-29 has good medicinal chemical properties, such as microsomal stability and solubility, showing potential clinical application value. | |||||||||||||||||||||
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