160554-87-0
160554-87-0
Chemical Structure
Ethonafide
Synonym(s): AMP-53; 6-Ethoxyazonafide
- CAS No.: 160554-87-0
- Formula:C22H22N2O3
- Molecular Weight:362.42
IUPAC Name: 2-(2-(dimethylamino)ethyl)-6-ethoxy-1H-dibenzo[de,h]isoquinoline-1,3(2H)-dione
InChIKey: UOUDIOOZKKFBBT-UHFFFAOYSA-N
SMILES: O=C1N(CCN(C)C)C(C2=CC=C(OCC)C3=CC4=CC=CC=C4C1=C23)=O
Biological Activity: Ethonafide (AMP-53) is an anthracene-containing derivative of Amonafide that belongs to the Azonafide series of anticancer agents. Ethonafide (AMP-53) inhibits topoisomerase II activity by stabilizing the enzyme-DNA complex, involving both topoisomerase IIα and β[1].
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Ethonafide | Ethonafide (AMP-53) is an anthracene-containing derivative of Amonafide that belongs to the Azonafide series of anticancer agents. Ethonafide (AMP-53) inhibits topoisomerase II activity by stabilizing the enzyme-DNA complex, involving both topoisomerase IIα and β. | |||||||||||||||||||||
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