1607004-34-1
Chemical Structure
ADAMTS-4/5-IN-1
- CAS No.: 1607004-34-1
- Formula:C20H22F3N3O3
- Molecular Weight:409.40
IUPAC Name: (S)-2-cyclopropyl-N-(((R)-4-cyclopropyl-2,5-dioxoimidazolidin-4-yl)methyl)-3-(4-(trifluoromethyl)phenyl)propanamide
InChIKey: JHOUEQAOHDTLPY-KXBFYZLASA-N
SMILES: FC(F)(F)C(C=C1)=CC=C1C[C@@H](C2CC2)C(NC[C@@]3(C4CC4)NC(NC3=O)=O)=O
Biological Activity: ADAMTS-4/5-IN-1 is an orally active, and selective dual ADAMTS-4/5 inhibitor with IC50 values of 2 nM for human ADAMTS-4 and human ADAMTS-5, respectively. ADAMTS-4/5-IN-1 exhibits high selectivity against MMP enzymes. ADAMTS-4/5-IN-1 reduces aggrecan degradation products in synovial fluid. ADAMTS-4/5-IN-1 can be used for the research of osteoarthritis[1].
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ADAMTS-4/5-IN-1 | ADAMTS-4/5-IN-1 is an orally active, and selective dual ADAMTS-4/5 inhibitor with IC50 values of 2 nM for human ADAMTS-4 and human ADAMTS-5, respectively. ADAMTS-4/5-IN-1 exhibits high selectivity against MMP enzymes. ADAMTS-4/5-IN-1 reduces aggrecan degradation products in synovial fluid. ADAMTS-4/5-IN-1 can be used for the research of osteoarthritis. | |||||||||||||||||||||
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