1609659-32-6
1609659-32-6
Chemical Structure
IBE-667
- CAS No.: 1609659-32-6
- Formula:C25H25N5O2
- Molecular Weight:427.51
IUPAC Name: N-(3-aminopropyl)-4-(1-(4-(methylcarbamoyl)phenyl)-1H-indazol-3-yl)benzamide
InChIKey: CGHZINICBUGRGZ-UHFFFAOYSA-N
SMILES: O=C(NC)C1=CC=C(C=C1)N2N=C(C=3C=CC(=CC3)C(=O)NCCCN)C=4C=CC=CC42
Biological Activity: IBE-667 is a LFA-1 integrin agonist with a Kd value of 52 nM. IBE-667 increases the stability of the open conformation of LFA-1 and enhances its affinity for ICAM-1. IBE-667 can be used in studies related to leukocyte adhesion deficiency[1][2][3].
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IBE-667 | IBE-667 is a LFA-1 integrin agonist with a Kd value of 52 nM. IBE-667 increases the stability of the open conformation of LFA-1 and enhances its affinity for ICAM-1. IBE-667 can be used in studies related to leukocyte adhesion deficiency. | |||||||||||||||||||||
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References
- [1]. Hintersteiner M, et al. Identification and X-ray co-crystal structure of a small-molecule activator of LFA-1-ICAM-1 binding. Angewandte Chemie (International ed. in English). 2014 Apr 22;53(17):4322-6.
- [2]. Tolomelli A, et al. Can Integrin Agonists Have Cards to Play against Cancer? A Literature Survey of Small Molecules Integrin Activators. Cancers. 2017 Jul 05;9(7):78.
- [3]. Abdullahi M, et al. Dynamics of allosteric modulation of lymphocyte function associated antigen-1 closure-open switch: unveiling the structural mechanisms associated with outside-in signaling activation. Biotechnology letters. 2017 Dec;39(12):1843-1851.
