1610017-20-3
Chemical Structure
BMS-986126
- CAS No.: 1610017-20-3
- Formula:C22H25FN6O2
- Molecular Weight:424.47
IUPAC Name: (R)-6-((1,6-naphthyridin-2-yl)amino)-4-(cyclopropylamino)-N-(2-fluoro-3-hydroxy-3-methylbutyl)nicotinamide
InChIKey: PXAWSYHMHMFXBD-GOSISDBHSA-N
SMILES: CC(C)(O)[C@H](F)CNC(C(C(NC1CC1)=C2)=CN=C2NC3=NC4=C(C=NC=C4)C=C3)=O
Biological Activity: BMS-986126 is a potent, selective, and orally active IRAK4 inhibitor (IC50 = 5.3 nM). BMS-986126 broadly inhibits MyD88-dependent signaling pathways. BMS-986126 demonstrates robust activity in the MRL/lpr and NZB/NZW murine models of lupus, inhibiting multiple pathogenic responses. BMS-986126 can be used for autoimmune diseases research, such as lupus erythematosus (SLE)[1].
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BMS-986126 | BMS-986126 is a potent, selective, and orally active IRAK4 inhibitor (IC50 = 5.3 nM). BMS-986126 broadly inhibits MyD88-dependent signaling pathways. BMS-986126 demonstrates robust activity in the MRL/lpr and NZB/NZW murine models of lupus, inhibiting multiple pathogenic responses. BMS-986126 can be used for autoimmune diseases research, such as lupus erythematosus (SLE). | |||||||||||||||||||||
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