1610703-09-7
1610703-09-7
Chemical Structure
CypK
Synonym(s): N-Cyclopropene-L-Lysine
- CAS No.: 1610703-09-7
- Formula:C12H20N2O4
- Molecular Weight:256.30
IUPAC Name: N6-(((2-methylcycloprop-2-en-1-yl)methoxy)carbonyl)-L-lysine
InChIKey: YMBQDEOCKOLCJG-AXDSSHIGSA-N
SMILES: N[C@@H](CCCCNC(OCC1C(C)=C1)=O)C(O)=O
Biological Activity: CypK (N-Cyclopropene-L-Lysine), a cyclopropene derivative of lysine, is efficiently incorporated into antibodies through genetic-code expansion. CypK is a minimal bioorthogonal handle for the creation of stable therapeutic protein conjugates[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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CypK | 99.45% | CypK (N-Cyclopropene-L-Lysine), a cyclopropene derivative of lysine, is efficiently incorporated into antibodies through genetic-code expansion. CypK is a minimal bioorthogonal handle for the creation of stable therapeutic protein conjugates. | ||||||||||||||||||||
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References
- [1]. Oller-Salvia B. Genetic Encoding of a Non-Canonical Amino Acid for the Generation of Antibody-Drug Conjugates Through a Fast Bioorthogonal Reaction. J Vis Exp. 2018 Sep 14;(139):58066. [Content Brief]
- [2]. Oller-Salvia B, et, al. Rapid and Efficient Generation of Stable Antibody-Drug Conjugates via an Encoded Cyclopropene and an Inverse-Electron-Demand Diels-Alder Reaction. Angew Chem Int Ed Engl. 2018 Mar 5;57(11):2831-2834. [Content Brief]
