1610974-55-4
1610974-55-4
Chemical Structure
PRN-371
- CAS No.: 1610974-55-4
- Formula:C20H21N5O2
- Molecular Weight:363.41
IUPAC Name: 2-(3-acrylamidophenyl)-N-(tert-butyl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxamide
InChIKey: RGYYZLGXRYSDRO-UHFFFAOYSA-N
SMILES: O=C(C1=CNC2=NC=C(C3=CC=CC(NC(C=C)=O)=C3)N=C21)NC(C)(C)C
Biological Activity: PRN-371 is a potent and selective JAK3 inhibitor. PRN371 effectively suppresses natural killer/T-cell lymphoma cell proliferation and induces apoptosis through abrogation of the JAK3-STAT signaling. PRN-371 exhibits antitumor activity and can be used for the research of cancer, such as hematological malignancies[1].
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PRN-371 | PRN-371 is a potent and selective JAK3 inhibitor. PRN371 effectively suppresses natural killer/T-cell lymphoma cell proliferation and induces apoptosis through abrogation of the JAK3-STAT signaling. PRN-371 exhibits antitumor activity and can be used for the research of cancer, such as hematological malignancies. | |||||||||||||||||||||
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