161262-29-9
Chemical Structure
Amotosalen
Synonym(s): S-59 free base
- CAS No.: 161262-29-9
- Formula:C17H19NO4
- Molecular Weight:301.34
IUPAC Name: 3-((2-aminoethoxy)methyl)-2,5,9-trimethyl-7H-furo[3,2-g]chromen-7-one
InChIKey: FERWCFYKULABCE-UHFFFAOYSA-N
SMILES: O=C1OC2=C(C)C(OC(C)=C3COCCN)=C3C=C2C(C)=C1
Biological Activity: Amotosalen (S-59 (free base)) is a light-activated, DNA and RNA-crosslinking psoralen compound, which is used to neutralise pathogens. Light-activated Amotosalen binds and permanently crosslinks DNA, preventing replication and thus stopping proliferation of donor T cells. Amotosalen can be used for the study of blood system pathogen reduction technology and graft-versus-host disease (GVHD)[1][2].
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Amotosalen | Amotosalen (S-59 (free base)) is a light-activated, DNA and RNA-crosslinking psoralen compound, which is used to neutralise pathogens. Light-activated Amotosalen binds and permanently crosslinks DNA, preventing replication and thus stopping proliferation of donor T cells. Amotosalen can be used for the study of blood system pathogen reduction technology and graft-versus-host disease (GVHD). | |||||||||||||||||||||
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References
- [1]. Amotosalen: Allogeneic Cellular Immunotherapies system, INTERCEPT Plasma System, INTERCEPT Platelet System, S 59. BioDrugs. 2003;17(1):66-8. [Content Brief]
- [2]. Lanteri MC, et al. Inactivation of a broad spectrum of viruses and parasites by photochemical treatment of plasma and platelets using amotosalen and ultraviolet A light. Transfusion. 2020 Jun;60(6):1319-1331. [Content Brief]
