161302-93-8
Chemical Structure
Afegostat hydrochloride
Synonym(s): D-Isofagomine hydrochloride; Isofagomine hydrochloride
- CAS No.: 161302-93-8
- Formula:C6H14ClNO3
- Molecular Weight:183.63
IUPAC Name: (3R,4R,5R)-5-(hydroxymethyl)piperidine-3,4-diol hydrochloride
InChIKey: XXPFHYCYDUDOIS-RWOHWRPJSA-N
SMILES: OC[C@@H]1[C@H]([C@@H](CNC1)O)O.Cl
Biological Activity: Afegostat hydrochloride (D-Isofagomine hydrochloride) is a potent β-galactosidase inhibitor with activity ameliorating GM1-gangliosidosis and Morquio B disease-associated mutations. Afegostat hydrochloride is able to induce the maturation of mutant β-galactosidase in fibroblasts from patients with GM1-gangliosidosis. Afegostat hydrochloride also promotes the reduction of keratin sulfate and oligosaccharide load in patient cells[1].
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Afegostat hydrochloride | Afegostat hydrochloride (D-Isofagomine hydrochloride) is a potent β-galactosidase inhibitor with activity ameliorating GM1-gangliosidosis and Morquio B disease-associated mutations. Afegostat hydrochloride is able to induce the maturation of mutant β-galactosidase in fibroblasts from patients with GM1-gangliosidosis. Afegostat hydrochloride also promotes the reduction of keratin sulfate and oligosaccharide load in patient cells. | |||||||||||||||||||||
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