161338-87-0
Chemical Structure
5(6)-Carboxyeosin-diacetate
- CAS No.: 161338-87-0
- Formula:C25H12Br4O9
- Molecular Weight:775.97
IUPAC Name: acetic acid compound with 2',4',5',7'-tetrabromo-3-oxo-3H-spiro[isobenzofuran-1,9'-xanthene]-3',6'-diyl diacetate (1:1)
InChIKey: PKFXFGISTOWVCX-UHFFFAOYSA-N
SMILES: BrC1=CC2=C(C(Br)=C1OC(C)=O)OC3=C(C=C(C(OC(C)=O)=C3Br)Br)C24C5=CC=CC=C5C(O4)=O.OC(C)=O
Biological Activity: 5(6)-Carboxyeosin-diacetate is a cell membrane-permeable biological dye, primarily used for detecting and modulating intracellular calcium-related processes. 5(6)-Carboxyeosin-diacetate acts as an inhibitor of plasma membrane calcium ATPase (PMCA), affecting intracellular calcium homeostasis by inhibiting calcium efflux. 5(6)-Carboxyeosin-diacetate, in its diacetate form, enters cells and is hydrolyzed by intracellular esterases to remove the acetate groups, releasing active Carboxyeosin, which inhibits plasma membrane Ca2+-ATPase through its ATPase activity, thereby inhibiting Ca2+ efflux and altering intracellular Ca2+ concentration. The fluorescence detection wavelength of 5(6)-Carboxyeosin-diacetate is approximately Ex/Em = 519/542 nm[1][2][3][4].
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5(6)-Carboxyeosin-diacetate | 5(6)-Carboxyeosin-diacetate is a cell membrane-permeable biological dye, primarily used for detecting and modulating intracellular calcium-related processes. 5(6)-Carboxyeosin-diacetate acts as an inhibitor of plasma membrane calcium ATPase (PMCA), affecting intracellular calcium homeostasis by inhibiting calcium efflux. 5(6)-Carboxyeosin-diacetate, in its diacetate form, enters cells and is hydrolyzed by intracellular esterases to remove the acetate groups, releasing active Carboxyeosin, which inhibits plasma membrane Ca2+-ATPase through its ATPase activity, thereby inhibiting Ca2+ efflux and altering intracellular Ca2+ concentration. The fluorescence detection wavelength of 5(6)-Carboxyeosin-diacetate is approximately Ex/Em = 519/542 nm. | |||||||||||||||||||||
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References
- [1]. Sherkhane P, et al. The plasma membrane Ca2+-ATPase2 (PMCA2) is involved in the regulation of Purkinje cell dendritic growth in cerebellar organotypic slice cultures. Neural plasticity. 2013;2013:321685.
- [2]. Schuh K, et al. Plasma membrane Ca2+ ATPase 4 is required for sperm motility and male fertility. The Journal of biological chemistry. 2004 Jul 02;279(27):28220-6.
- [3]. Green AK, et al. Effects on the hepatocyte [Ca2+]i oscillator of inhibition of the plasma membrane Ca2+ pump by carboxyeosin or glucagon-(19-29). Cell calcium. 1997 Aug;22(2):99-109.
- [4]. Yoshida K, et al. Ca efflux via plasma membrane Ca-ATPase mediates chemotaxis in ascidian sperm. Scientific reports. 2018 Nov 09;8(1):16622.
