161416-61-1
161416-61-1
Chemical Structure
Pozanicline dihydrochloride
Synonym(s): ABT-089 dihydrochloride
- CAS No.: 161416-61-1
- Formula:C11H18Cl2N2O
- Molecular Weight:265.18
IUPAC Name: (S)-2-methyl-3-(pyrrolidin-2-ylmethoxy)pyridine dihydrochloride
InChIKey: UGVSESCRKJTJAK-XRIOVQLTSA-N
SMILES: [H]Cl.[H]Cl.CC(N=CC=C1)=C1OC[C@@H]2CCCN2
Biological Activity: Pozanicline dihydrochloride (ABT-089 dihydrochloride) is an orally bioavailable nicotinic acetylcholine receptor (nAChR) agonist with a Ki of 16.7 nM for binding to [3H]cytisine sites[1]. Pozanicline is an α4β2-selective nAChR agonist, which binds to rat brain α4β2 nAChR with a Ki of 17 nM while binding to α7 nAChR is insignificant[2].
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Pozanicline dihydrochloride | 99.06% | Pozanicline dihydrochloride (ABT-089 dihydrochloride) is an orally bioavailable nicotinic acetylcholine receptor (nAChR) agonist with a Ki of 16.7 nM for binding to [3H]cytisine sites. Pozanicline is an α4β2-selective nAChR agonist, which binds to rat brain α4β2 nAChR with a Ki of 17 nM while binding to α7 nAChR is insignificant. | ||||||||||||||||||||
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Pozanicline dihydrochloride (Standard) | ≥98% | Pozanicline dihydrochloride (Standard) is the analytical standard of Pozanicline (dihydrochloride) (HY-110160). This product is intended for research and analytical applications. Pozanicline dihydrochloride (ABT-089 dihydrochloride) is an orally bioavailable nicotinic acetylcholine receptor (nAChR) agonist with a Ki of 16.7 nM for binding to [3H]cytisine sites. Pozanicline is an α4β2-selective nAChR agonist, which binds to rat brain α4β2 nAChR with a Ki of 17 nM while binding to α7 nAChR is insignificant. | ||||||||||||||||||||
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References
- [1]. Lin NH, et al. Structure-activity studies on 2-methyl-3-(2(S)-pyrrolidinylmethoxy) pyridine (ABT-089): an orally bioavailable 3-pyridyl ether nicotinic acetylcholine receptor ligand with cognition-enhancing properties. J Med Chem. 1997 Jan 31;40(3):385-90 [Content Brief]
- [2]. Marks MJ, et al. Selectivity of ABT-089 for α4β2 and α6β2 nicotinic acetylcholine receptors in brain. Biochem Pharmacol. 2009 Oct 1;78(7):795-802. [Content Brief]
