1616400-50-0
1616400-50-0
Chemical Structure
ZEN-2759
- CAS No.: 1616400-50-0
- Formula:C17H16N2O2
- Molecular Weight:280.32
IUPAC Name: 1-benzyl-5-(3,5-dimethylisoxazol-4-yl)pyridin-2(1H)-one
InChIKey: CIJOVPIWGFQZFF-UHFFFAOYSA-N
SMILES: O=C1C=CC(C2=C(ON=C2C)C)=CN1CC3=CC=CC=C3
Biological Activity: ZEN-2759 is a non-covalent BRD4 inhibitor with IC50 values of 0.23, 0.08, and 0.28 μM for BRD4 (BD1), BRD4 (BD2), and BRD4 (BD1BD2), respectively. ZEN-2759 can be used for cancer research[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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ZEN-2759 | 99.51% | ZEN-2759 is a non-covalent BRD4 inhibitor with IC50 values of 0.23, 0.08, and 0.28 μM for BRD4 (BD1), BRD4 (BD2), and BRD4 (BD1BD2), respectively. ZEN-2759 can be used for cancer research. | ||||||||||||||||||||
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References
- [1]. Li B, et al. Targeting Protein-Protein Interaction with Covalent Small-Molecule Inhibitors. Curr Top Med Chem. 2019;19(21):1872-1876.
- [2]. Kharenko OA, et al. Design and Characterization of Novel Covalent Bromodomain and Extra-Terminal Domain (BET) Inhibitors Targeting a Methionine. Journal of medicinal chemistry. 2018 Sep 27;61(18):8202-8211. [Content Brief]
