1616622-10-6
Chemical Structure
(±)-Spiro-oxanthromicin A
- CAS No.: 1616622-10-6
- Formula:C36H26O10
- Molecular Weight:618.59
IUPAC Name: 2,5,6',10'-tetrahydroxy-4,5',6,8'-tetramethyl-7',10-dioxo-2',7'-dihydro-10H-spiro[anthracene-9,3'-benzo[de]anthracene]-3,9'-dicarboxylic acid
InChIKey: GLAYNHMYQPENCN-UHFFFAOYSA-N
SMILES: CC(C=C1C(C(C2=C3O)=CC=C3C)(CC=C(C(C4=C5C)=CC(O)=C5C(O)=O)C1=C6C4=O)C(C(C2=O)=C7C)=CC(O)=C7C(O)=O)=C6O
Biological Activity: (±)-Spiro-oxanthromicin A (Compound 4), a polyketide, is a K-Ras inhibitor with an IC50 of 26.7 μM. (±)-Spiro-oxanthromicin A can be isolated from soil-derived Streptomyces sp. (±)-Spiro-oxanthromicin A can mislocalize oncogenic mutant K-Ras from the plasma membrane of intact MDCK cells. (±)-Spiro-oxanthromicin A can be used for cancers research[1].
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(±)-Spiro-oxanthromicin A | (±)-Spiro-oxanthromicin A (Compound 4), a polyketide, is a K-Ras inhibitor with an IC50 of 26.7 μM. (±)-Spiro-oxanthromicin A can be isolated from soil-derived Streptomyces sp. (±)-Spiro-oxanthromicin A can mislocalize oncogenic mutant K-Ras from the plasma membrane of intact MDCK cells. (±)-Spiro-oxanthromicin A can be used for cancers research. | |||||||||||||||||||||
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