1620142-65-5
1620142-65-5
Chemical Structure
R-348 choline
Synonym(s): R-932348 choline
- CAS No.: 1620142-65-5
- Formula:C28H35FN6O5S
- Molecular Weight:586.68
IUPAC Name: 2-hydroxy-N,N,N-trimethylethan-1-aminium ((5-((5-fluoro-4-((4-(prop-2-yn-1-yloxy)phenyl)amino)pyrimidin-2-yl)amino)-2-methylphenyl)sulfonyl)(propionyl)amide
InChIKey: LZMBOMHVTNXZSS-UHFFFAOYSA-M
SMILES: C[N+](CCO)(C)C.CCC([N-]S(=O)(C1=CC(NC2=NC=C(C(NC3=CC=C(C=C3)OCC#C)=N2)F)=CC=C1C)=O)=O
Biological Activity: R-348 (R-932348) choline is a potent and orally active JAK3 and Syk inhibitor. R-348 reduces IFN-γ, IL-6, and IL-10 expression. R-348 effectively diminishes acute cardiac allograft rejection[1].
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R-348 choline | R-348 (R-932348) choline is a potent and orally active JAK3 and Syk inhibitor. R-348 reduces IFN-γ, IL-6, and IL-10 expression. R-348 effectively diminishes acute cardiac allograft rejection. | |||||||||||||||||||||
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