1620896-55-0
1620896-55-0
Chemical Structure
F-SLOH
- CAS No.: 1620896-55-0
- Formula:C30H30ClFN2O3
- Molecular Weight:521.02
InChIKey: ZUXVASZSUFMGKK-UHFFFAOYSA-M
SMILES: COCCOCCN1C2=CC=C(/C=C/C3=CC=[N+](CCO)C4=C3C=CC=C4)C=C2C5=CC(F)=CC=C51.[Cl-]
Biological Activity: F-SLOH is a brain-penerant and orally active TFEB activator and amyloid-β inhibitor with an IC50 of 3.4 μM against amyloid-β. F-SLOH promotes nuclear translocation of TFEB, driving autophagy and lysosomal biogenesis. F-SLOH reduces amyloid-β oligomers and Tau aggregates via autophagy lysosomal degradation pathway. F-SLOH can be used for the research of Alzheimer’s disease[1].
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F-SLOH | F-SLOH is a brain-penerant and orally active TFEB activator and amyloid-β inhibitor with an IC50 of 3.4 μM against amyloid-β. F-SLOH promotes nuclear translocation of TFEB, driving autophagy and lysosomal biogenesis. F-SLOH reduces amyloid-β oligomers and Tau aggregates via autophagy lysosomal degradation pathway. F-SLOH can be used for the research of Alzheimer’s disease. | |||||||||||||||||||||
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