162100-15-4
162100-15-4
Chemical Structure
SB-215505
- CAS No.: 162100-15-4
- Formula:C19H16ClN3O
- Molecular Weight:337.80
IUPAC Name: 6-chloro-5-methyl-N-(quinolin-5-yl)indoline-1-carboxamide
InChIKey: HOVMHIRTZYQSKM-UHFFFAOYSA-N
SMILES: O=C(N1CCC2=C1C=C(Cl)C(C)=C2)NC3=C4C=CC=NC4=CC=C3
Biological Activity: SB-215505 is an orally active and subtype-selective 5-HT2B receptor antagonist with pKi values of 8.3, 6.77, 7.66 for 5-HT2B, 5-HT2A, 5-HT2C, respectively[1]. SB-215505 increases wakefulness and motor activity in rats[2].
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SB-215505 | 98.91% | SB-215505 is an orally active and subtype-selective 5-HT2B receptor antagonist with pKi values of 8.3, 6.77, 7.66 for 5-HT2B, 5-HT2A, 5-HT2C, respectively. SB-215505 increases wakefulness and motor activity in rats. | ||||||||||||||||||||
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References
- [1]. C Reavill, et al. Attenuation of haloperidol-induced catalepsy by a 5-HT2C receptor antagonist. Br J Pharmacol. 1999 Feb;126(3):572-4. [Content Brief]
- [2]. Sandor Kantor, et al. Increased wakefulness, motor activity and decreased theta activity after blockade of the 5-HT2B receptor by the subtype-selective antagonist SB-215505. J Pharmacol. 2004 Aug;142(8):1332-42. [Content Brief]
