1621065-22-2
Chemical Structure
S1P5 receptor antagonist 1
- CAS No.: 1621065-22-2
- Formula:C28H39NO3
- Molecular Weight:437.62
IUPAC Name: 1-((2-(((1r,4r)-4-(tert-butyl)cyclohexyl)oxy)-4-methylnaphthalen-1-yl)methyl)piperidine-4-carboxylic acid
InChIKey: KVRMGFKQCUEJMS-HZCBDIJESA-N
SMILES: C(C=1C2=C(C(C)=CC1O[C@@H]3CC[C@@H](C(C)(C)C)CC3)C=CC=C2)N4CCC(C(O)=O)CC4
Biological Activity: S1P5 receptor antagonist 1 is a selective, blood-brain barrier-permeable S1P5 receptor antagonist with an EC50 of 0.1 nM and a Ki of 4.4 nM. S1P5 receptor antagonist 1 inhibits the migration of natural killer cells towards sphingosine 1-phosphate in vitro, with no effect on T cell migration. S1P5 receptor antagonist 1 can be used in the research of central nervous system diseases[1].
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S1P5 receptor antagonist 1 | S1P5 receptor antagonist 1 is a selective, blood-brain barrier-permeable S1P5 receptor antagonist with an EC50 of 0.1 nM and a Ki of 4.4 nM. S1P5 receptor antagonist 1 inhibits the migration of natural killer cells towards sphingosine 1-phosphate in vitro, with no effect on T cell migration. S1P5 receptor antagonist 1 can be used in the research of central nervous system diseases. | |||||||||||||||||||||
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