1621326-32-6
Chemical Structure
para-Nitroblebbistatin
Synonym(s): (-)-para-Nitroblebbistatin
- CAS No.: 1621326-32-6
- Formula:C18H15N3O4
- Molecular Weight:337.33
IUPAC Name: (S)-3a-hydroxy-6-methyl-1-(4-nitrophenyl)-1,2,3,3a-tetrahydro-4H-pyrrolo[2,3-b]quinolin-4-one
InChIKey: KAUXNLHXGQGFOS-GOSISDBHSA-N
SMILES: O=C1[C@]2(C(N(CC2)C3=CC=C(C=C3)[N+]([O-])=O)=NC4=C1C=C(C=C4)C)O
Biological Activity: para-Nitroblebbistatin is a derivative of Blebbistatin (HY-13813) and an inhibitor of myosin II. para-Nitroblebbistatin is photostable, non-cytotoxic, and non-phototoxic. para-Nitroblebbistatin can serve as an ideal substitute for Blebbistatin (HY-13813) to study the role of myosin II in physiology, development, and cell biology[1][2].
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para-Nitroblebbistatin | para-Nitroblebbistatin is a derivative of Blebbistatin (HY-13813) and an inhibitor of myosin II. para-Nitroblebbistatin is photostable, non-cytotoxic, and non-phototoxic. para-Nitroblebbistatin can serve as an ideal substitute for Blebbistatin (HY-13813) to study the role of myosin II in physiology, development, and cell biology. | |||||||||||||||||||||
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References
- [1]. Radnai L, et al. A simple and robust cell-based assay for the discovery of novel cytokinesis inhibitors. J Biol Methods. 2020 Sep 17;7(3):e136. [Content Brief]
- [2]. Képiró M, et al. para-Nitroblebbistatin, the non-cytotoxic and photostable myosin II inhibitor. Angew Chem Int Ed Engl. 2014 Jul 28;53(31):8211-5. [Content Brief]
