1622253-00-2
Chemical Structure
Albicidin
- CAS No.: 1622253-00-2
- Formula:C44H38N6O12
- Molecular Weight:842.81
IUPAC Name: (S,E)-4-(4-(4-(3-cyano-2-(4-(3-(4-hydroxyphenyl)-2-methylacrylamido)benzamido)propanamido)benzamido)-2-hydroxy-3-methoxybenzamido)-2-hydroxy-3-methoxybenzoic acid
InChIKey: NZSWNNDHPOTJNH-VEJILBAHSA-N
SMILES: O=C(C1=C(C(OC)=C(C=C1)NC(C2=CC=C(C=C2)NC([C@H](CC#N)NC(C3=CC=C(C=C3)NC(/C(C)=C/C4=CC=C(C=C4)O)=O)=O)=O)=O)O)NC5=C(C(O)=C(C=C5)C(O)=O)OC
Biological Activity: Albicidin is a peptide antibiotic with phytotoxic activity. Albicidin potently inhibits bacterial and plant DNA gyrase at nanomolar concentrations, blocks DNA replication, and exhibits excellent antibacterial efficacy against multidrug-resistant bacteria. Albicidin possesses bactericidal activity against Gram-positive and Gram-negative microorganisms, and acts as a virulence factor for the systemic plant infection by Xanthomonas albilineans. Albicidin can be used in studies related to bacterial infections and sugarcane leaf blight[1][2].
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Albicidin | Albicidin is a peptide antibiotic with phytotoxic activity. Albicidin potently inhibits bacterial and plant DNA gyrase at nanomolar concentrations, blocks DNA replication, and exhibits excellent antibacterial efficacy against multidrug-resistant bacteria. Albicidin possesses bactericidal activity against Gram-positive and Gram-negative microorganisms, and acts as a virulence factor for the systemic plant infection by Xanthomonas albilineans. Albicidin can be used in studies related to bacterial infections and sugarcane leaf blight. | |||||||||||||||||||||
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References
- [1]. Kretz J, et al. Total synthesis of albicidin: a lead structure from Xanthomonas albilineans for potent antibacterial gyrase inhibitors. Angew Chem Int Ed Engl. 2015;54(6):1969-1973. [Content Brief]
- [2]. Hashimi SM, et al. The phytotoxin albicidin is a novel inhibitor of DNA gyrase. Antimicrob Agents Chemother. 2007;51(1):181-187. [Content Brief]
