162412-70-6
Chemical Structure
PD-156707
- CAS No.: 162412-70-6
- Formula:C28H25NaO9
- Molecular Weight:528.48
IUPAC Name: sodium (Z)-2-(benzo[d][1,3]dioxol-5-yl)-4-(4-methoxyphenyl)-4-oxo-3-(3,4,5-trimethoxybenzyl)but-2-enoate
InChIKey: ZLHQEGFYBMZQGM-RKVLWQGQSA-M
SMILES: O=C(/C(C1=CC=C2OCOC2=C1)=C(C(C3=CC=C(C=C3)OC)=O)/CC4=CC(OC)=C(C(OC)=C4)OC)O[Na]
Biological Activity: PD-156707 is an orally active, nonpeptide and selective Endothelin-A receptor antagonist. PD-156707 binds to human ET-A and ET-B receptors with Ki values of 0.17 nM and 133.8 nM, respectively. PD-156707 shows reversal of established chronic hypoxic pulmonary hypertension in rats. PD-156707 can be used for the study of diseases associated with abnormal ET-A receptor activation, particularly pulmonary hypertension, stroke, and heart failure[1][2].
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PD-156707 | 99.92% | PD-156707 is an orally active, nonpeptide and selective Endothelin-A receptor antagonist. PD-156707 binds to human ET-A and ET-B receptors with Ki values of 0.17 nM and 133.8 nM, respectively. PD-156707 shows reversal of established chronic hypoxic pulmonary hypertension in rats. PD-156707 can be used for the study of diseases associated with abnormal ET-A receptor activation, particularly pulmonary hypertension, stroke, and heart failure. | ||||||||||||||||||||
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References
- [1]. Andrew C. G. Uprichard, et al. PD- 156707: A Selective Endothelin-A Receptor Antagonist. Cardiovascular Drug Reviews Vol. 16, No. 2, pp. 89-104.
- [2]. D P Ignasiak, et al. Effects of endothelin ETA receptor antagonism with PD 156707 on hemodynamics and renal vascular resistance in rabbits. Eur J Pharmacol. 1997 Mar 5;321(3):295-300. [Content Brief]
