1624297-26-2
Chemical Structure
M3 mAChR agonist 1
- CAS No.: 1624297-26-2
- Formula:C29H33F3N6O4S
- Molecular Weight:618.67
IUPAC Name: (R)-1-(5-((5-((2-ethylpyrrolidin-1-yl)methyl)-4-(4-methoxy-3-(trifluoromethyl)phenyl)thiazol-2-yl)carbamoyl)pyrazin-2-yl)piperidine-4-carboxylic acid
InChIKey: FBQAMPBIZPAOEQ-LJQANCHMSA-N
SMILES: O=C(C1CCN(C2=NC=C(C(NC3=NC(C4=CC=C(OC)C(C(F)(F)F)=C4)=C(CN5[C@H](CC)CCC5)S3)=O)N=C2)CC1)O
Biological Activity: M3 mAChR agonist 1 is an M3-preferring M3/M5 mAChR dual positive allosteric modulators (PAM). M3 mAChR agonist 1 shows excellent subtype selectivity over other subtypes of mAChRs including M1, M2, and M4 mAChRs. M3 mAChR agonist 1 increases the contraction of isolated rat bladder strips by modulating the M3 muscarinic acetylcholine receptor, leading to enhanced signaling pathways. M3 mAChR agonist 1 can be used for the research of endocrinology[1].
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M3 mAChR agonist 1 | M3 mAChR agonist 1 is an M3-preferring M3/M5 mAChR dual positive allosteric modulators (PAM). M3 mAChR agonist 1 shows excellent subtype selectivity over other subtypes of mAChRs including M1, M2, and M4 mAChRs. M3 mAChR agonist 1 increases the contraction of isolated rat bladder strips by modulating the M3 muscarinic acetylcholine receptor, leading to enhanced signaling pathways. M3 mAChR agonist 1 can be used for the research of endocrinology. | |||||||||||||||||||||
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