162554-02-1
162554-02-1
Chemical Structure
2',5'-Dideoxy-3'-ATP
- CAS No.: 162554-02-1
- Formula:C10H16N5O11P3
- Molecular Weight:475.18
InChIKey: ZJGUOEYCABTFNH-DSYKOEDSSA-N
SMILES: NC1=NC=NC2=C1N=CN2[C@H]3C[C@H](OP(OP(OP(O)(O)=O)(O)=O)(O)=O)[C@@H](C)O3
Biological Activity: 2',5'-Dideoxy-3'-ATP is an adenylate cyclase inhibitor. 2',5'-Dideoxy-3'-ATP exerts linear noncompetitive inhibition via binding to the distinct P-site. 2',5'-Dideoxy-3'-ATP binds and stabilizes the dimeric form of Mycobacterium avium adenylyl cyclase Ma1120 to inhibit activity[1][2][3].
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2',5'-Dideoxy-3'-ATP | 2',5'-Dideoxy-3'-ATP is an adenylate cyclase inhibitor. 2',5'-Dideoxy-3'-ATP exerts linear noncompetitive inhibition via binding to the distinct P-site. 2',5'-Dideoxy-3'-ATP binds and stabilizes the dimeric form of Mycobacterium avium adenylyl cyclase Ma1120 to inhibit activity. | |||||||||||||||||||||
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References
- [1]. Désaubry L, et al. 2',5'-Dideoxyadenosine 3'-polyphosphates are potent inhibitors of adenylyl cyclases. J Biol Chem. 1996 Feb 2;271(5):2380-2. [Content Brief]
- [2]. Vadakkadathmeethal K, et al. Fluorescence-based adenylyl cyclase assay adaptable to high throughput screening. Comb Chem High Throughput Screen. 2007;10(4):289-298. [Content Brief]
- [3]. Barathy DV, et al. Autoinhibitory mechanism and activity-related structural changes in a mycobacterial adenylyl cyclase. J Struct Biol. 2015;190(3):304-313. [Content Brief]
