1627902-21-9
1627902-21-9
Chemical Structure
JNJ-54175446
- CAS No.: 1627902-21-9
- Formula:C18H13ClF4N6O
- Molecular Weight:440.78
IUPAC Name: (R)-(2-chloro-3-(trifluoromethyl)phenyl)(1-(5-fluoropyrimidin-2-yl)-4-methyl-1,4,6,7-tetrahydro-5H-[1,2,3]triazolo[4,5-c]pyridin-5-yl)methanone
InChIKey: CWFVVQFVGMFTBD-SECBINFHSA-N
SMILES: ClC1=C(C=CC=C1C(N2CCC3=C(N=NN3C4=NC=C(F)C=N4)[C@H]2C)=O)C(F)(F)F
Biological Activity: JNJ-54175446 is a potent and selective brain penetrant P2X7 receptor antagonist, with pIC50s of 8.46 and 8.81 for hP2X7 receptor and rP2X7 receptor, respectively.
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JNJ-54175446 | 98.84% | JNJ-54175446 is a potent and selective brain penetrant P2X7 receptor antagonist, with pIC50s of 8.46 and 8.81 for hP2X7 receptor and rP2X7 receptor, respectively. | ||||||||||||||||||||
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