1628342-10-8
1628342-10-8
Chemical Structure
PF-04677490
- CAS No.: 1628342-10-8
- Formula:C17H21N5O2
- Molecular Weight:327.38
IUPAC Name: 7,8-dimethoxy-N-(1-(5-methyl-1H-pyrazol-3-yl)propan-2-yl)quinazolin-4-amine
InChIKey: JTROLECZHRVLFM-UHFFFAOYSA-N
SMILES: CC(CC1=NNC(C)=C1)NC2=C3C=CC(OC)=C(C3=NC=N2)OC
Biological Activity: PF-04677490 is a PDE1 inhibitor (IC50: 21 nM). PF-04677490 has IC50s of 21 nM, 83 nM, and 118 nM for PDE1B1, PDE1C, and PDE1A, respectively. PF-04677490 efficaciously inhibits cAMP- and cGMP-hydrolytic activity[1].
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PF-04677490 | PF-04677490 is a PDE1 inhibitor (IC50: 21 nM). PF-04677490 has IC50s of 21 nM, 83 nM, and 118 nM for PDE1B1, PDE1C, and PDE1A, respectively. PF-04677490 efficaciously inhibits cAMP- and cGMP-hydrolytic activity. | |||||||||||||||||||||
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