1628478-15-8
Chemical Structure
ISR-IN-1
- CAS No.: 1628478-15-8
- Formula:C22H22Cl2F2N2O4
- Molecular Weight:487.32
IUPAC Name: N,N'-((1r,4r)-cyclohexane-1,4-diyl)bis(2-(4-chloro-3-fluorophenoxy)acetamide)
InChIKey: BLLMXZJTGLCEBP-HDJSIYSDSA-N
SMILES: FC(C=C1OCC(N[C@H](CC2)CC[C@@H]2NC(COC3=CC(F)=C(C=C3)Cl)=O)=O)=C(C=C1)Cl
Biological Activity: ISR-IN-1 is an integrated stress response (ISR) inhibitor targeting eIF2B. ISR-IN-1 enhances eIF2B guanine nucleotide exchange factor activity, stabilizes eIF2B heteropentamer dimers via symmetrical protein-protein interface binding, and releases global protein synthesis inhibition from phosphorylated eIF2αα. ISR-IN-1 can be used for the research of prion disease[1].
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ISR-IN-1 | 98.92% | ISR-IN-1 is an integrated stress response (ISR) inhibitor targeting eIF2B. ISR-IN-1 enhances eIF2B guanine nucleotide exchange factor activity, stabilizes eIF2B heteropentamer dimers via symmetrical protein-protein interface binding, and releases global protein synthesis inhibition from phosphorylated eIF2αα. ISR-IN-1 can be used for the research of prion disease. | ||||||||||||||||||||
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